Methods and nucleic acids for analyses of cellular proliferative disorders

US10385402B2 · kind B2 · utility

Assignee

• EPIGENOMICS AG · DE

Inventors

• Catherine E. Lofton-Day · Brier, US
• Andrew Z. Sledziewski · Shoreline, US
• Ralf Lesche · Berlin, DE
• Matthias Schuster · Weinheim, DE
• Juergen Distler · Berlin, DE
• Reimo Tetzner · Berlin, DE
• Thomas Hildmann · Berlin, DE
• Fabian Model · Berlin, DE
• Xiaoling Song · Woodinville, US

Key dates

• Filing date: Mar 23, 2016
• Grant date: Aug 20, 2019
• Expiry date: Dec 30, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.