Long term hematopoietic stem cell specific reporter mouse and uses thereof
US10386361B2 · kind B2 · utility
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Key dates
| Filing date | Jun 7, 2017 |
| Grant date | Aug 20, 2019 |
| Priority date | — |
| Expiry date | Jun 10, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/47
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Hoxb5 identifies long-term hematopoietic stem cells. Expression of Hoxb5 distinguishes between LT-HSCs and non-LT-HSCs, and the marker identifies substantially all LT-HSC in the bone marrow. By utilizing fluorescent proteins under the endogenous expression control of Hoxb5, LT-HSC can be monitored and isolated, including without limitation detection and monitoring of HSC in bone morrow; production of LT-HSC from pluripotent stem cells such as iPS cells; for analysis of early stage LT-HSC; in screening methods for expansion and manipulation of LT-HSC, and the like.
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