Metabolic flux measurement, imaging and microscopy

US10386371B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Benjamin P. Bowen · Tempe, US
• Katherine B. Louie · Walnut Creek, US
• Trent R. Northen · Walnut Creek, US
• Marc K. Hellerstein · Kensington, US

Key dates

• Filing date: Sep 7, 2012
• Grant date: Aug 20, 2019
• Expiry date: May 24, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Provided herein are methods for measuring molecular flux rates of molecules of interest in a tissue sample in spatially-organized manner and generating output (e.g., an image, a heat map, a contour map, a table or a database) representing the molecular flux rates of each spatially-defined location of the sample. Provided herein are also the output, as well as systems and computer-readable medium with computer-executable instructions for determining molecular flux rates of molecules of interest in the sample.