Methods, systems, and apparatuses for tissue ablation using electrolysis and permeabilization
US10390874B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 14, 2014 |
| Grant date | Aug 27, 2019 |
| Priority date | — |
| Expiry date | Nov 22, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2205/52
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis treatment and cellular permeabilization treatment to a site in tissue. A system disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through the aqueous matrix to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. The composition of the electrodes may be chosen in accordance with the desired products produced and electroporation effects. An apparatus is disclosed that may be in the form of electrodes the electrolysis and electrodes for electroporation applied to the tissue. An apparatus is disclosed that may be used for treating internal tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.