Patent · US Active

Inhibition of formation of amyloid β-protein fibrils using cactus mucilage extracts

US10391135B2 · kind B2 · utility

0Cited by

1References

4Claims

0Family size

Assignee

University of South Florida · US

Inventors

Norma A. Alcantar · Tampa, US
David Morgan · Scottsdale, US
Zeinab Veisi · Tampa, US
Leonid Breydo · Tampa, US
Vladimir N. Uversky · Tampa, US
Ryan G. Toomey · Tampa, US
Tunan Peng · Land O' Lakes, US
Eva Stephanie Lobbens · Farum, DK

Key dates

Filing date	Sep 15, 2017
Grant date	Aug 27, 2019
Priority date	—
Expiry date	Sep 15, 2037

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2236/53
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method of treating an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.