Combined use of a vector encoding a modified receptor and its exogenous agonist in the treatment of seizures
US10391145B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 6, 2015 |
| Grant date | Aug 27, 2019 |
| Priority date | — |
| Expiry date | Mar 6, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods and materials for treating a seizure disorder such as epilepsy in a patient which employ a vector encoding a modified receptor, the so-called “DREADD” receptor being characterised by (i) a decreased responsiveness to its endogenous activating ligand (ii) a retained or enhanced responsiveness to an exogenous agonist. The modified receptor is expressed in neurons of a seizure focus in brain of the patient, and an exogenous agonist is administered which activates the modified receptor to reversibly alters the excitability of the neurons in the seizure focus leading to synaptic silencing or other inhibition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.