Crystal of salt of novel 3-azabicyclo[3.1.0]hexane derivative and pharmaceutical use thereof
US10392345B2 · kind B2 · utility
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26Claims
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Key dates
| Filing date | May 19, 2016 |
| Grant date | Aug 27, 2019 |
| Priority date | — |
| Expiry date | May 19, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are a crystal comprising a compound, which has μ-opioid receptor antagonistic action, few side effects, and high safety, and having high purity and excellent physical properties (stability, solubility, etc.), and a method for producing the crystal.The crystal is a crystal of a salt comprising: a compound represented by a formula (I) [wherein R2 is a hydrogen atom or a halogen atom, and R1 is a group selected from the group consisting of and an acid selected from the group consisting of hydrochloric acid, hydrobromic acid, and oxalic acid, or a hydrate thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.