Patent · US Active

Method for preparing nilotinib intermediate

US10392351B2 · kind B2 · utility

6Cited by

0References

4Claims

0Family size

Assignees

SUZHOU LIXIN PHARMACEUTICAL CO., LTD. · CN
Xuenong Xu · CN

Inventors

Xuenong Xu · Suzhou, CN
Deli Zeng · Suzhou, CN
Liang Shu · Rizhao, CN
Qing Zhang · Tianjin, CN
Zhijian Bao · Suzhou, CN
Jia Xue · Suzhou, CN
Jian Su · Suzhou, CN
Zhe Wang · Xiangtan City, CN
Wenjie Zhou · Nanhu, CN
Lingling Xie · Suzhou, CN

Key dates

Filing date	Jul 7, 2016
Grant date	Aug 27, 2019
Priority date	—
Expiry date	Jul 7, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D233/61
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed in the present invention is a method for preparing nilotinib intermediate 3-(4-methyl-1H-imidazol-1-yl)-5trifluoromethyl phenylamine (I). The method comprises the following steps: taking trifluorotoluene as an initial material, and preparing the nilotinib intermediate (I) by nitration, bromization, condensation and reduction successively Compared with the prior art, the preparation method has the following advantages: a relatively high yield, the raw materials are easily obtained, a concise process and few side reactions, and is adapted to industrial production, so the development of an economic technology of the bulk drug is promoted.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.