Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors

US10392392B2 · kind B2 · utility

Assignee

• TOLERO PHARMACEUTICALS, INC. · US

Inventors

• Yong Xu · Midvale, US
• Benjamin Gary Brenning · Zapopan, MX
• Steven G. Kultgen · Hillsborough Township, US
• Xiaohui Liu · Fujian, CN
• Michael David Saunders · Sandy, US
• Koc-Kan Ho · Mount Kisco, US

Key dates

• Filing date: Jul 11, 2018
• Grant date: Aug 27, 2019
• Expiry date: Jul 11, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides substituted imidazo[1,2-b]pyridazines that are useful as protein kinase inhibitors and have one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. For example, a compound having the following structure: Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.