Cytotoxic peptides and conjugates thereof

US10392421B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Bernhard Hubert Geierstanger · Solana Beach, US
• Jan Grunewald · San Diego, US
• Yunho Jin · San Diego, US
• Weijia Ou · San Diego, US
• Tetsuo Uno · San Diego, US
• Yongqin Wan · Irvine, US
• Xing Wang · San Diego, US

Key dates

• Filing date: Apr 24, 2018
• Grant date: Aug 27, 2019
• Expiry date: Apr 24, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.