Patent · US Active

Vascularized in vitro perfusion devices, methods of fabricating, and applications thereof

US10392595B2 · kind B2 · utility

0Cited by
2References
20Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJul 6, 2016
Grant dateAug 27, 2019
Priority date—
Expiry dateJul 27, 2036

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2533/30
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

A bona fide adaptable in vitro microcirculation model is provided by integrating a 3-D printed network of endothelial-cell lined perfusion channels, formed via sacrificial casting in a gel matrix, with a native, adaptable microvasculature matured from native microvessels added to the gel matrix. Responsive vascular adaptation exhibited by the in vitro microcirculation is physiologically relevant. Methods for fabricating, devices, models and investigative platforms for pharmaceutical applications, vascular mechanism and microvessel-parenchyma interaction studies, and vascularizing strategies for tissue engineering applications are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.