Patent · US Active

Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro

US10392619B2 · kind B2 · utility

2Cited by
23References
8Claims
0Family size

Inventor

Key dates

Filing dateJan 29, 2016
Grant dateAug 27, 2019
Priority date—
Expiry dateJan 29, 2036

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2320/51
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Compositions and method for down modulating target gene expression which RNA interference, as well as methods for administering said compositions are disclosed. The method comprises administering a first oligonucleotide strand to a cell, incubating the cells for a time period suitable for uptake of the first oligo nucleotide strand prior to administration of a second oligonucleotide strand, wherein the first strand and the second strand form an intracellular duplex which is effective to catalyze degradation of gene target mRNA or inhibit translation of said mRNA.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.