AAV8 vector with enhanced functional activity and methods of use thereof
US10392632B2 · kind B2 · utility
10Cited by
0References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 14, 2012 |
| Grant date | Aug 27, 2019 |
| Priority date | — |
| Expiry date | Feb 14, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This application relates to the fields of gene therapy and molecular biology. In accordance with the present invention, an adeno-associated virus (AAV) vector comprising an altered capsid protein is provided. More specifically, this invention provides adeno-associated viral vectors comprising protein capsid variants which accelerate vector breakdown and clearance, thereby reducing undesirable immune responses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.