Universal molecular processor for precision medicine

US10393726B2 · kind B2 · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• Cornell University · IT
• BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE · US

Inventors

• Steven A. Soper · Baton Rouge, US
• Francis Barany · Baltimore, US
• Sunggook Park · Baton Rouge, US
• Michael C. Murphy · Baton Rouge, US
• Collin J. McKinney · Durham, US
• John William Efcavitch · San Carlos, US
• Mateusz Hupert · Lawrence, US

Key dates

• Filing date: Mar 23, 2016
• Grant date: Aug 27, 2019
• Expiry date: Mar 23, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6874
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention is directed to a device that comprises a biomolecular processor and one or more nanotubes. Each biomolecular processor comprises a bioreactor chamber defined by a solid substrate, a plurality of spaced support structures within said bioreactor chamber and attached to the solid substrate, and one or more capture molecules immobilized to some or all of said plurality of spaced support structures, said one or more capture molecules suitable to bind to a portion of a target nucleic acid molecule in a sample. The device also comprises one or more nanotubes defined by the solid substrate and fluidically coupled to the bioreactor chamber.