Cellular-based method for determining the biological activity of defibrotide
US10393731B2 · kind B2 · utility
3Cited by
28References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 23, 2015 |
| Grant date | Aug 27, 2019 |
| Priority date | — |
| Expiry date | Nov 23, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5064
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to cell-based methods for determining the biological activity of defibrotide. In particular, the invention provides a method for assessing the potency of defibrotide by assessing the viability of mammalian cells in the presence of at least one cytotoxic agent and one or more concentrations of defibrotide. Such methods are particularly useful for standardizing pharmaceutical compositions comprising defibrotide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.