Method for the diagnosis and prognosis of cancer

US10393745B2 · kind B2 · utility

Assignee

• The USA, as represented by the Secretary, Department of Heath and Human Services · US

Inventors

• Majda Haznadar · Bethesda, US
• Ewy Mathe · Bethesda, US
• Andrew D. Patterson · Bethesda, US
• Curtis C. Harris · Bethesda, US
• Frank J. Gonzalez · Bethesda, US
• Kristopher W. Krausz · Columbia, US
• Soumen Manna · Bethesda, US

Key dates

• Filing date: Jul 11, 2014
• Grant date: Aug 27, 2019
• Expiry date: Jul 11, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention provides methods and materials for diagnosing cancer in an individual using a tissue, blood or urine sample from the patient. Specifically, the disclosed method comprises determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, Cortisol sulfate and N-acetylneuraminic acid. The present invention also provides a method for determining the prognosis of a cancer patient by determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, Cortisol sulfate and N-acetylneuraminic acid. Also provided are kits for detecting cancer or determining the prognosis of a cancer patient.