Methods and compositions for targeting cancer stem cells
US10398672B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Apr 29, 2015 |
| Grant date | Sep 3, 2019 |
| Priority date | — |
| Expiry date | Apr 29, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Aspects of the disclosure relate to methods that involve activating the Protein Kinase A (PKA) pathway to induce cancer stem cells (CSCs) to undergo a mesenchymal to epithelial transition. Methods provided herein are useful, in some embodiments, because they render CSCs amenable to treatment with conventional cancer therapies. In some embodiments, methods are provided that involve assaying PKA pathway activity to identify compounds that selectively target CSCs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.