Edible oral strip or wafer dosage form containing ion exchange resin for taste masking

US10398746B2 · kind B2 · utility

Assignee

• LTS Lohmann Therapie-Systeme AG · DE

Inventors

• Michael Li · Hillsborough Township, US
• Markus Krumme · Neuwied, DE

Key dates

• Filing date: Jan 31, 2017
• Grant date: Sep 3, 2019
• Expiry date: Jan 31, 2037

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29L2007/007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An edible oral film strip dosage form containing an unpalatable basic active pharmaceutical ingredient and an ion exchange resin as a primary taste masking agent, along with an optional acidic agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.