Pharmaceutical compositions of water soluble peptides with poor solubility in isotonic conditions and methods for their use
US10398751B2 · kind B2 · utility
0Cited by
9References
2Claims
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Key dates
| Filing date | May 21, 2018 |
| Grant date | Sep 3, 2019 |
| Priority date | — |
| Expiry date | May 21, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/36
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions comprising water soluble peptides with poor solubility in isotonic solutions which exhibit enhanced bioavailability with reduced adverse effects including injection site reactions. Methods are also disclosed for using such compositions for the treatment of diseases including, but not limited to, cancer, type 2 diabetes, acromegaly, metabolic disorders, endocrine disorders, exocrine tumors, and hormone-related tumors. Methods to reduce adverse injection site reactions and improve bioavailability are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.