Methods for preventing or treating certain disorders by inhibiting binding of IL-4 and/or IL-13 to their respective receptors

US10398754B2 · kind B2 · utility

Assignees

• Pieris Pharmaceuticals GmbH · DE
• ASTRAZENECA AB · SE

Inventors

• Andreas Hohlbaum · Paunzhausen, DE
• Laurent Audoly · Mahwah, US
• Beverly Koller · Carrboro, US

Key dates

• Filing date: Jun 7, 2018
• Grant date: Sep 3, 2019
• Expiry date: Jun 7, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to methods of treating, ameliorating or preventing a disorder comprising administering a therapeutically effective amount of a composition comprising a protein which inhibits the ligand of Uniprot #P05112 and/or the ligand of Uniprot #P35225 from binding to their respective receptors to a subject in need thereof. In some embodiments, the disorder is preferably associated with an increase of the Th2 immune response. In some embodiments, administration is preferably locally to the lung in order to treat, ameliorate or prevent allergic asthma, rhinitis, conjunctivitis, lung fibrosis, cystic fibrosis, chronic obstructive pulmonary disease, pulmonary alveolar proteinosis or adult respiratory distress syndrome.