Sterilisation of S-nitrosothiols
US10398775B2 · kind B2 · utility
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15Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 21, 2016 |
| Grant date | Sep 3, 2019 |
| Priority date | — |
| Expiry date | Mar 21, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2202/21
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides a method of sterilizing an S-nitrosothiol, for example S-nitrosoglutathione, without reduction of purity by more than about 5.0% through degradation. The invention allows sterile S-nitrosothiol or a sterile pharmaceutical pre-composition comprising S-nitrosothiol, wherein the S-nitrosothiol is in dry solid form, to be produced. The sterile pharmaceutical pre-composition is mixed with one or more diluents, excipients, carriers, additional active agents, or any combination thereof, for example sterile saline, to prepare a pharmaceutical composition of S-nitrosothiol for use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.