Substituted benzofuranyl and benzoxazolyl compounds and uses thereof

US10399963B2 · kind B2 · utility

Assignee

• Karyopharm Therapeutics Inc. · US

Inventors

• Erkan Baloglu · Stoneham, US
• Sharon Shacham · Gdera, IL
• William Senapedis · Millis, US
• Dilara McCauley · Cambridge, US
• Yosef Landesman · Brookline, US
• Gali Golan · Shoeva, IL
• Ori Kalid · Rehovot, IL
• Sharon Shechter · Andover, US

Key dates

• Filing date: Dec 4, 2017
• Grant date: Sep 3, 2019
• Expiry date: Dec 4, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula A: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.