Proteins specific for calcitonin gene-related peptide

US10400016B2 · kind B2 · utility

Assignee

• Pieris Pharmaceuticals GmbH · DE

Inventors

• Gabriele Matschiner · Munich, DE
• Christine Rothe · Freising, DE
• Alexander Wiedenmann · Ulm, DE
• Rachida Siham Bel Aiba · Munich, DE
• Marlon Hinner · Freising, DE
• Andrea Allersdorfer · Wolnzach, DE
• Bradley M. Lunde · Lebanon, US
• Kazufumi Kubota · Tokyo, JP
• Mitsuhiro Makino · Shinagawa, JP
• Sakiko Takahashi · Tokyo, JP
• Ryuji Hashimoto · Tokyo, JP
• Tohru Takahashi · Tokyo, JP
• Mamoru Otoyo · Tokyo, JP

Key dates

• Filing date: Dec 7, 2016
• Grant date: Sep 3, 2019
• Expiry date: Dec 7, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/31
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides hNGAL muteins that bind CGRP and can be used in various application including pharmaceutical applications, for example, migraine. The present disclosure also concerns methods of making one or more muteins described herein as well as compositions and combinations comprising one or more of such muteins. The present disclosure further relates to nucleic acid molecules encoding such muteins and to methods for generation of such muteins and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of these muteins as well as compositions and combinations comprising one or more of such muteins.