Therapeutic biologic for treatment of hepatocellular carcinoma
US10400026B2 · kind B2 · utility
4Cited by
6References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 20, 2016 |
| Grant date | Sep 3, 2019 |
| Priority date | — |
| Expiry date | Sep 20, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugates provided by the invention or compositions provided by the invention, such as pharmaceutical compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.