Flavivirus neutralizing antibodies and methods of use thereof
US10400032B2 · kind B2 · utility
1Cited by
20References
3Claims
0Family size
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Key dates
| Filing date | Nov 20, 2017 |
| Grant date | Sep 3, 2019 |
| Priority date | — |
| Expiry date | Nov 20, 2037 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides antibodies that neutralize flavivirus and methods of use thereof. These antibodies are derived from mAb11 which recognizes West Nile virus E protein and is cross-reactive with members of the flavivirus family, including Denge virus. The antibodies of the present invention prevent antibody-dependent enhancement of a viral infection by having a modified Fc region that does not bind to the Fcγ receptor. The invented antibody is used to treat flaviviral infections and symptoms thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.