RNA-based, amplification-free, organism identification using nano-enabled electronic detection

US10400270B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Andre Knoesen · Davis, US
• Paul A. Feldstein · Sacramento, US
• Joshua Hihath · Davis, US
• Erkin Seker · Davis, US
• Maria Louise Marco · Davis, US
• Bryce W. Falk · Davis, US

Key dates

• Filing date: Sep 12, 2017
• Grant date: Sep 3, 2019
• Expiry date: Sep 12, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6825
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system.