Mitochondrial DNA deletion between about residues 12317-16254 for use in the detection of cancer
US10400290B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Apr 6, 2018 |
| Grant date | Sep 3, 2019 |
| Priority date | — |
| Expiry date | Apr 6, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying mitochondrial DNA mutation in the sample and comparing the level of mtDNA mutation with a reference value. The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.