Label-free detection of small and large molecule interactions, and activities in biological systems
US10401298B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Jan 23, 2018 |
| Grant date | Sep 3, 2019 |
| Priority date | — |
| Expiry date | Jan 23, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG02B21/365
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A system for quantitative detection and analysis of the interactions of molecules with molecular receptors on the surfaces of biological cells based on detecting a mechanical deformation in the membrane of a cell associated with the molecular interactions, which works for both large and small molecules. The mechanical deformation can be detected with high precision in real time from an optical image of the cell with a differential detection method. The system can be also used to detect the electrical activities, such as ion channel opening and closing, as well as action potential propagation in neuronal cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.