Patent · US Active

Digital holographic method of measuring cellular activity and measuring apparatus with improved stability

US10401793B2 · kind B2 · utility

0Cited by
20References
17Claims
0Family size

Inventor

Key dates

Filing dateNov 22, 2016
Grant dateSep 3, 2019
Priority date—
Expiry dateNov 22, 2036

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG03H2001/045
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

Motility contrast imaging (MCI) is a depth-resolved holographic technique to extract cellular and subcellular motion inside tissue. The holographic basis of the measurement technique makes it highly susceptible to mechanical motion. The motility contrast application, in particular, preferably includes increased mechanical stability because the signal is based on time-varying changes caused by cellular motion, which should not be confused with mechanical motion of the system. Apparatus for motility contrast imaging that provides increased mechanical stability are disclosed. It is based on common-path configurations, in which the signal and reference beams share optical elements in their paths to the detector. The two beams share mechanical motions in common, and hence those motions do not contribute to the signal.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.