System and method for personalized computation of tissue ablation extent based on medical images
US10402535B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 13, 2015 |
| Grant date | Sep 3, 2019 |
| Priority date | — |
| Expiry date | Aug 28, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2034/105
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method and system for personalized computation of tissue ablation extent based on medical images of a patient is disclosed. A patient-specific anatomical model of the liver and liver vessels is estimated from medical image data of a patient. Blood flow in the liver and liver vessels is simulated. An ablation simulation is performed that uses a bio-heat model to simulate heat diffusion due to an ablation based on the simulated blood flow and a cellular necrosis model to simulate cellular necrosis in the liver based on the simulated heat diffusion. Personalized tissue parameters of the bio-heat model and the cellular necrosis model are estimated based on observed results of a preliminary ablation procedure. Planning of the ablation procedure is then performed using the personalized bio-heat equation and the cellular necrosis model. The model can be subsequently refined as more ablation observations are obtained.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.