Method of preparing composite granule comprising low-substituted hydroxypropyl cellulose and rapid release preparation
US10406107B2 · kind B2 · utility
1Cited by
4References
5Claims
0Family size
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Key dates
| Filing date | Jun 4, 2013 |
| Grant date | Sep 10, 2019 |
| Priority date | — |
| Expiry date | Jun 4, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2018
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a base material for dry direct tableting, the material being excellent in a binding property and disintegrability. More specifically, provided is a method of preparing a composite granule comprising at least a step of granulating a second sugar or sugar alcohol while adding thereto an aqueous dispersion comprising at least low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of 5 to 16% by weight, polyvinyl alcohol, a first sugar or sugar alcohol, and water.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.