Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the H2O2 level in cancer cells of a subject
US10406125B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Oct 14, 2016 |
| Grant date | Sep 10, 2019 |
| Priority date | — |
| Expiry date | Oct 14, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2440/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase H2O2 level in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce H2O2 in comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.