Patent · US Active

Telodendrimers with enhanced drug delivery

US10406233B2 · kind B2 · utility

3Cited by

0References

6Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Juntao Luo · Jamesville, US
Kit S. Lam · Davis, US

Key dates

Filing date	Dec 19, 2012
Grant date	Sep 10, 2019
Priority date	—
Expiry date	Feb 3, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08L71/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.