Single wall nanotube constructs and uses thereof

US10406236B2 · kind B2 · utility

Assignee

• Sloan Kettering Institute for Cancer Research · US

Inventors

• David A. Scheinberg · New York, US
• Michael R. McDevitt · New York, US
• Christophe Antczak · Arlington, US
• Debjit Chattopadhyay · Pennington, US
• Rena May · Baltimore, US
• Jon Njardarson · Tucson, US
• Mark Reid Phillips · New York, US

Key dates

• Filing date: Apr 24, 2017
• Grant date: Sep 10, 2019
• Expiry date: Apr 24, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C01B2202/36
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.