Double-labeled probe for molecular imaging and use thereof

US10406246B2 · kind B2 · utility

Assignee

• Deutsches Krebsforschungszentrum · DE

Inventors

• Matthias Eder · Freiburg (Elbe), DE
• Klaus Kopka · Dossenheim, DE
• Martin Schaefer · Penzberg, DE
• Ulrike Bauder-Wuest · Schriesheim, DE
• Uwe Haberkorn · Schwetzingen, DE

Key dates

• Filing date: Jul 18, 2014
• Grant date: Sep 10, 2019
• Expiry date: Nov 2, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/582
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: (A) at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; and (C) at least one dye moiety; wherein said compound has a molecular weight of not more than 5 kDa. Further, the invention refers to a method for producing such compound and to the in vivo and in vitro uses thereof.