Nucleoside phosphoramidates useful for the treatment of viral infections and preparation thereof

US10407456B2 · kind B2 · utility

Assignee

• Quimica Sintetica, S.A. · ES

Inventors

• Giuseppe Barreca · Milano, IT
• Marcello Rasparini · Pavia, IT
• Andrea Poggiali · Caronno Pertusella, IT
• Luca Carcone · Cervaro, IT
• Roberto Rocco Tufaro · Sozzago, IT
• Giovanni Marras · Novara, IT
• Maurizio Taddei · Colle di Val d'Elsa, IT
• Elena Cini · Gambassi Terme, IT

Key dates

• Filing date: Mar 25, 2016
• Grant date: Sep 10, 2019
• Expiry date: Mar 25, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Two processes are described for preparing, in different diastereomeric purity degrees, the compound (S)-isopropyl-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)-phosphoryl)amino) propanoate, having the formula given below, known as Sofosbuvir and used for the treatment of hepatitis C.