Patent · US Active

Means and methods for producing Neisseria meningitidis capsular polysaccharides of low dispersity

US10407703B2 · kind B2 · utility

0Cited by

0References

24Claims

0Family size

Assignee

MEDIZINISCHE HOCHSCHULE HANNOVER · DE

Inventors

Timm Fiebig · Hannover, DE
Tim Keys · Uster, CH
Friedrich Freiberger · Wunstorf, DE
Angela Romanow · Laatzen, DE
Andrea Bethe · Hildesheim, DE
Monika Berger · Sehnde, DE
Rita Gerardy-Schahn · Hiddenhausen, DE

Key dates

Filing date	Apr 17, 2015
Grant date	Sep 10, 2019
Priority date	—
Expiry date	Apr 17, 2035

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/55544
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to in vitro methods for producing Neisseria meningitidis capsular polysaccharides which have a defined length. The present invention also relates to compositions comprising at least one capsule polymerase, at least one donor carbohydrate and at least one acceptor carbohydrate, wherein the ratio of donor carbohydrate to acceptor carbohydrate is a ratio from 10:1 to 400:1. Moreover, the present invention provides truncated versions of the capsule polymerases of Neisseria meningitidis serogroups A and X. Also provided herein are pharmaceuticals, in particular vaccines, comprising the synthetic capsular polysaccharides of Neisseria meningitidis which have a defined length. Furthermore, the invention provides for methods for the production of said vaccines.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.