Plasmonic imaging and detection of single DNA molecules
US10408757B2 · kind B2 · utility
6Cited by
1References
16Claims
0Family size
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Key dates
| Filing date | Jan 2, 2015 |
| Grant date | Sep 10, 2019 |
| Priority date | — |
| Expiry date | Dec 25, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/552
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Method and system to remove background noise with a differential approach in optical imaging is disclosed. The differential approach moves the sample position laterally over a small distance, and a differential image is generated from the images recorded before and after the lateral translation. This approach can significantly improve the image quality of objects, including single DNA molecules, for label-free optical imaging techniques, such as surface plasmon resonance imaging. Disclosed imaging technique provides high-resolution genome-wide restriction maps of single DNA molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.