Mutated parvovirus structural proteins as vaccines

US10408834B2 · kind B2 · utility

Assignees

• Medi&Gene Inc. · DE
• Ludwig-Maximilians-Universitat Munchen · DE
• UNIVERSITAET ZU KOELN · DE

Inventors

• Hildegard BUENING · Cologne, DE
• John Nieland · Munich, DE
• Luca Perabo · Cologne, DE
• Daniela Kuehn · Munich, DE
• Kerstin Pinotossi · Munich, DE
• Michael Hallek · Cologne, DE
• Markus Hoerer · Planegg, DE
• Mirko Ritter · Bernried, DE

Key dates

• Filing date: Nov 2, 2015
• Grant date: Sep 10, 2019
• Expiry date: Nov 6, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is related to a method for identifying a parvovirus mutated structural protein capable of specifically binding to a binder for an antigen, a parvovirus mutated structural protein which comprises at least one B-cell epitope heterologous to the parvovirus, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a virus or cell comprising the protein, a method of preparing the protein, a medicament comprising the protein, nucleic acid or multimeric structure and its use.