Methods and devices for ultrasound contrast-assisted therapy

US10413278B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Xucai Chen · Glenshaw, US
• Jianjun Wang · Troy, US
• John J. Pacella · Pittsburgh, US
• Flordeliza Villanueva · Pittsburgh, US

Key dates

• Filing date: Jun 27, 2013
• Grant date: Sep 17, 2019
• Expiry date: Apr 21, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2007/0052
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Various methods of performing ultrasound contrast assisted therapy are provided. One such method includes delivering a plurality of microbubble-based ultrasound contrast agents to a target area and disrupting the microbubble-based ultrasound contrast agents by delivering tone bursts of ultrasound to the target area. The oscillation of the microbubble-based ultrasound contrast agents can be achieved by delivering ultrasound tone bursts of greater than 5 acoustic cycles with a pulse repetition frequency of between 0.01 and 20 Hz, with pressure greater than 0.3 MPa.