Three-dimensinoal scaffolds, methods for fabricating the same, and methods of treating a peripheral nerve or spinal cord injury

US10413391B2 · kind B2 · utility

Assignees

• Rensselaer Polytechnic Institute · US
• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Andres Hurtado · Baltimore, US
• Ryan J. Gilbert · Troy, US
• Han Bing Wang · Houghton, US
• Jared M. Cregg · Cleveland, US
• Michael E. Mullins · Houghton, US
• Martin Oudega · Terrace, US

Key dates

• Filing date: Apr 1, 2011
• Grant date: Sep 17, 2019
• Expiry date: Feb 3, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/38
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

One aspect of the invention provides a three-dimensional scaffold including at least one layer of highly-aligned fibers. The at least one layer of highly-aligned fibers is curved in a direction substantially perpendicular to a general direction of the fibers. Another aspect of the invention provides a method for fabricating a three-dimensional scaffold. The method includes: electro spinning a plurality of fibers to produce at least one layer of highly-aligned fibers and forming the at least one layer of highly-aligned fibers into a three-dimensional scaffold without disturbing the alignment of the highly-aligned polymer fibers. A further aspect of the invention provides methods for using a three-dimensional scaffold to treat nerve or spinal cord injury.