Treatment of Rb-negative tumors using topoisomerase with cyclin dependent kinase 4/6 inhibitors
US10413547B2 · kind B2 · utility
6Cited by
25References
3Claims
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Key dates
| Filing date | Sep 26, 2018 |
| Grant date | Sep 17, 2019 |
| Priority date | — |
| Expiry date | Sep 26, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/695
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is in the area of improved therapeutic combinations for and methods of treating selected retinoblastoma (Rb)-negative cancers and Rb-negative abnormal cellular proliferative disorders using particular topoisomerase inhibitors and specific cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. In one aspect, the improved treatment of select Rb-negative cancers is disclosed using specific compounds disclosed herein in combination with a topoisomerase I inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.