Method and intermediate for preparing tulathromycin
US10414746B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 18, 2016 |
| Grant date | Sep 17, 2019 |
| Priority date | — |
| Expiry date | Jan 18, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method and an intermediate for preparing a tulathromycin. The method includes the following step: in an organic solvent, subjecting a compound represented by formula (II) and an n-propylamine to a ring-opening addition shown below to obtain a tulathromycin represented by formula (I), wherein the organic solvent is a 1,2-propandiol. Tulathromycin obtained using the method has a high purity, with an HPLC purity being 95% and above, and up to 99% and above, satisfying a required purity for preparing a tulathromycin as a pharmaceutical formulation. The method has a high yield, is simple to operate, and is more suitable for industrial production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.