Patent · US Active

Exocyclic nitrogen atom protected nucleoside and method for producing and using the same

US10414790B2 · kind B2 · utility

0Cited by

0References

13Claims

0Family size

Assignee

The Regents of the University of Colorado · US

Inventors

Marvin H. Caruthers · Boulder, US
Subhadeep Roy · Boulder, US

Key dates

Filing date	Aug 3, 2013
Grant date	Sep 17, 2019
Priority date	—
Expiry date	Feb 24, 2035

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides nucleosides an exocyclic amine-protected nucleoside of the formula: A-B where A is a 5′-protected ribose, 5′-protected-2-deoxyribose, 5′-protected-3′-phosphoramidite ribose, or 5′-protected-3′-phosphoramidite-2-deoxyribose moiety; and B is a nucleobase having an exocyclic amine group that is protected with di-tert-butylisobutylsilyl (“BIBS”) protecting group. Use of BIBS protecting group provides an exocyclic amine-protected nucleoside that is stable to a wide variety of reaction conditions associated with oligonucleotide synthesis. The present invention also provides, oligonucleotides comprising the same, and methods for producing the same.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.