Minor histocompatibility antigens and uses thereof
US10414813B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Feb 9, 2016 |
| Grant date | Sep 17, 2019 |
| Priority date | — |
| Expiry date | Feb 9, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70539
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel minor histocompatibility antigens (MiHAs) are described. These novel MiHAs were selected based on two features: (i) they are encoded by loci with a minor allele frequency (MAF) of at least 0.05; and (ii) they have adequate tissue distribution. Compositions, nucleic acids and cells related to these novel MiHAs are also described. The present application also discloses the use of these novel MiHAs, and related compositions, nucleic acids and cells, in applications related to cancer immunotherapy, for example for the treatment of hematologic cancers such as leukemia.
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