Patent · US Active

Process for the preparation of sugammadex and its intermediates

US10414829B2 · kind B2 · utility

2Cited by

0References

12Claims

0Family size

Assignee

Fresenius Kabi iPSUM S.r.l · IT

Inventors

Walter Cabri · Sant Celoni, ES
Antonio Ricci · Birsfelden, CH
Jacopo Zanon · Venezia, IT
Saswata Lahiri · Sindhar, IN
Govind Singh · Ghaziabad, IN
Dominik Heckmann · Friedberg, DE

Key dates

Filing date	Nov 23, 2016
Grant date	Sep 17, 2019
Priority date	—
Expiry date	Nov 23, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08L5/16
WIPO fieldMacromolecular chemistry, polymers
WIPO sectorChemistry

Abstract

The present application provides an improved process for the preparation of sugammadex which comprises the halogenation of γ-cyclodextrin in a suitable organic solvent to give 6-per-deoxy-6-per-halo-γ-cyclodextrin, wherein halo is bromo or chloro, reacting the halogenated γ-cyclodextrin with 3-mercaptopropionic acid in the presence of alkoxide base to obtain sugammadex of formula I. This application also provides isolation of 6-per-deoxy-6-per-chloro-γ-cyclodextrin as a crystalline compound and its use for the preparation of sugammadex of formula (I).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.