Phage-displayed single-chain variable fragment libraries and uses thereof
US10415033B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Nov 28, 2018 |
| Grant date | Sep 17, 2019 |
| Priority date | — |
| Expiry date | Nov 28, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in having a specific CS combination and a specific sequence in each CDR. The present scFv library is useful in efficiently producing different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.