Method and device for freeze-drying drug liposomes powder assisted by variable-frequency alternating-current electric field

US10415881B2 · kind B2 · utility

Assignee

• South China University of Technology · CN

Inventors

• Dawen Sun · Foshan, CN
• Lina Cheng · 流花街道, CN
• Zhiwei Zhu · Plainsboro, US
• Xin'an Zeng · 流花街道, CN
• Qijun Wang · 流花街道, CN
• Zi Zhang · Huai'an, CN

Key dates

• Filing date: Dec 29, 2015
• Grant date: Sep 17, 2019
• Expiry date: Jul 6, 2036

Classification

• Technology area (CPC F): Mechanical Engineering; Lighting; Heating
• CPC primary: F26B25/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention discloses a method for freeze-drying drug liposomes powder assisted by a variable-frequency alternating-current electric field, which includes the following steps: (1) preparing a drug-liposome suspension sample; (2) dehydrating the sample under a 1-10 kHz, 3-10 kV high-voltage alternating current; (3) freezing and drying the sample treated in step (2) at −20° C. to −40° C., under a 10-25 kHz, 0.2-1 kV high-voltage alternating current, until completion of the freezing process; and (4) heating and drying the sample in a vacuum until completion of sublimation and desorption, and obtaining the drug liposomes freeze-dried powder. The present invention not only greatly shortens a freezing and drying time, but also controls a size of nuclei and ice crystals, further ensuring a quality of the freeze-dried powder.