Method of measuring efficacy of treatment for multiple sclerosis
US10420503B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 30, 2016 |
| Grant date | Sep 24, 2019 |
| Priority date | — |
| Expiry date | Nov 15, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61D99/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method of measuring efficacy of treatment of multiple sclerosis (MS) in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals or a standard of care to determine efficacy. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Another embodiment uses a Fourier transform on a circle and a linear combination. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.