Therapeutic target for the treatment of cancers and related therapies and methods
US10420742B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Sep 14, 2017 |
| Grant date | Sep 24, 2019 |
| Priority date | — |
| Expiry date | Sep 14, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/343
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are compositions and methods for treating or preventing certain cancers in a subject. In certain embodiments such compositions and methods generally relate to the use of G-coupled protein receptor 40 (GPR40) agonists to inhibit the growth or induce apoptosis of certain cancer cells. The compositions and related methods disclosed herein may be used to treat subjects affected by cancers, such as melanoma, medullary thyroid carcinoma, malignant peripheral nerve sheath tumors and neuroblastoma, and to reduce the incidence of metastases in such affected subjects.
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